Breast cancer cell-associated endopeptidase EC 24.11 modulates proliferative response to bombesin
1999
Breast cancer cell endopeptidase and its effect on growth response
publication
Author Information
Author(s): Burns D M, Walker B, Gray J, Nelson J
Primary Institution: School of Biomedical Sciences, University of Ulster at Jordanstown
Hypothesis
The study investigates how the endopeptidase EC 24.11 affects the growth response of breast cancer cells to bombesin.
Conclusion
The endopeptidase EC 24.11 significantly modulates the growth of T47D breast cancer cells and their response to bombesin.
Supporting Evidence
- GRP-like immunoreactivity was detected in T47D breast cancer cells but not in the conditioned medium.
- The addition of the endopeptidase inhibitor phosphoramidon enhanced T47D cell growth in response to bombesin.
Takeaway
Researchers found that a specific enzyme in breast cancer cells helps them grow more when exposed to a certain substance called bombesin.
Methodology
The study used radioimmunoassay and high-performance liquid chromatography to analyze GRP-like peptides in breast cancer cell lines.
Digital Object Identifier (DOI)
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