The Role of Neurotensin Receptor-1 in Breast Cancer Progression
Author Information
Author(s): Dupouy Sandra, Viardot-Foucault Véronique, Alifano Marco, Souazé Frédérique, Plu-Bureau Geneviève, Chaouat Marc, Lavaur Anne, Hugol Danielle, Gespach Christian, Gompel Anne, Forgez Patricia
Primary Institution: INSERM-UPMC CDR Saint-Antoine, Hôpital Saint-Antoine, Paris, France
Hypothesis
NTSR1 contributes to the progression of invasive ductal breast cancer.
Conclusion
High expression of NTSR1 is associated with worse prognosis in breast cancer patients.
Supporting Evidence
- NTSR1 high expression is linked to larger tumor size and more positive lymph nodes.
- Patients with high NTSR1 expression have a significantly worse prognosis.
- NTS is expressed in both normal and cancerous breast tissues.
- NTSR1 expression is an independent prognostic factor.
- High NTSR1 expression correlates with SBR grade 3.
- Patients with high NTSR1 expression have a ten-year survival rate of 66.2%.
Takeaway
This study found that a protein called NTSR1 can make breast cancer worse, and patients with more of it tend to have a harder time.
Methodology
The study used immunohistochemistry and RT-PCR to analyze NTS and NTSR1 expression in breast cancer tissues.
Potential Biases
Potential biases in patient selection and data collection methods.
Limitations
The study is retrospective and relies on previously collected clinical data.
Participant Demographics
Mean age of participants was 57.96 years, with 65% being postmenopausal.
Statistical Information
P-Value
p<0.01
Confidence Interval
[1.04–26.88]
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website