Comparing Quality of Life Questionnaires for Colorectal Cancer Patients
Author Information
Author(s): Uwer Lionel, Rotonda Christine, Guillemin Francis, Miny Joëlle, Kaminsky Marie-Christine, Mercier Mariette, Tournier-Rangeard Laetitia, Leonard Isabelle, Montcuquet Philippe, Rauch Philippe, Conroy Thierry
Primary Institution: Centre Alexis Vautrin, Department of Medical Oncology, Nancy, France
Hypothesis
The study aims to compare the responsiveness of the EORTC QLQ-C30, QLQ-CR38, and FACT-C quality of life questionnaires in patients with colorectal cancer.
Conclusion
The EORTC QLQ-C30 questionnaire appears to be more responsive in patients receiving chemotherapy.
Supporting Evidence
- The EORTC QLQ-C30 was more responsive in patients receiving chemotherapy, particularly in functional scales.
- Patients reported significant changes in health status during treatment.
- Responsiveness varied according to the type of treatment received.
Takeaway
This study looked at how well different questionnaires can tell if colorectal cancer patients feel better or worse during treatment. The EORTC QLQ-C30 was the best at showing changes in health.
Methodology
This was a prospective study involving 127 patients with colorectal cancer, comparing the responsiveness of three quality of life questionnaires during chemotherapy and radiotherapy.
Potential Biases
The study may have a response-shift phenomenon, where patients adapt their health perceptions, potentially skewing results.
Limitations
The study's responsiveness analysis relied only on patients who perceived their health as improved, and did not analyze those with a decline in health.
Participant Demographics
{"age":{"mean":64,"chemotherapy_group":60,"radiotherapy_group":66},"gender":{"men":81,"women":46},"marital_status":{"single":7,"married":97,"widower":12,"divorced":11},"localisation":{"colon":56,"rectum":71},"disease_status":{"non_metastatic":80,"metastatic":45}}
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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