Differential Effects of Peptidoglycan Recognition Proteins on Experimental Atopic and Contact Dermatitis Mediated by Treg and Th17 Cells
2011
Effects of Peptidoglycan Recognition Proteins on Skin Inflammation
Sample size: 9
publication
Evidence: high
Author Information
Author(s): Park Shin Yong, Gupta Dipika, Kim Chang H., Dziarski Roman
Primary Institution: Indiana University School of Medicine–Northwest
Hypothesis
PGRPs play a role in the development of atopic dermatitis and contact dermatitis.
Conclusion
Pglyrp3 and Pglyrp4 protect against severe atopic dermatitis by promoting Treg cell accumulation and inhibiting Th17 cell activation.
Supporting Evidence
- Pglyrp3 and Pglyrp4 deficient mice showed increased sensitivity to atopic dermatitis.
- Reduced recruitment of Treg cells and increased Th17 cell activation were observed in Pglyrp3 and Pglyrp4 deficient mice.
- Vitamin D treatment increased Treg cells and reduced inflammation in Pglyrp3 deficient mice.
Takeaway
Some proteins in our skin help keep it healthy by stopping too much inflammation when we have skin allergies.
Methodology
The study used Pglyrp-deficient mice and mouse models of chemically-induced atopic dermatitis and contact dermatitis.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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