Tau Exon 10 Alternative Splicing and Tauopathies
Author Information
Author(s): Liu Fei, Gong Cheng-Xin
Primary Institution: New York State Institute for Basic Research in Developmental Disabilities
Hypothesis
Dysregulation of tau exon 10 alternative splicing and the resulting imbalance of 3R-tau and 4R-tau is sufficient to cause neurodegeneration and dementia.
Conclusion
Understanding the regulation of tau exon 10 splicing can provide insights into tauopathies and potential therapeutic targets.
Supporting Evidence
- Six isoforms of tau are expressed in the adult human brain due to alternative splicing.
- Dysregulation of tau exon 10 splicing can lead to neurodegeneration.
- Altered 3R-tau/4R-tau ratios have been observed in several tauopathies.
Takeaway
This study looks at how a specific part of the tau protein can change in people with brain diseases, which might help us find new ways to treat these conditions.
Methodology
The article reviews the gene structure, transcripts, and protein isoforms of tau, focusing on the regulation of exon 10 splicing.
Digital Object Identifier (DOI)
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