Complete genome analysis of Streptococcus gallolyticus subsp. gallolyticus
Author Information
Author(s): Hinse Dennis, Vollmer Tanja, Rückert Christian, Blom Jochen, Kalinowski Jörn, Knabbe Cornelius, Dreier Jens
Primary Institution: Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen
Hypothesis
What are the genetic elements and pathomechanisms underlying the pathogenicity of Streptococcus gallolyticus subsp. gallolyticus?
Conclusion
The study reveals significant genetic factors related to the pathogenesis and adhesion of Streptococcus gallolyticus subsp. gallolyticus, including the presence of a novel plasmid that may facilitate lateral gene transfer.
Supporting Evidence
- The genome of S. gallolyticus subsp. gallolyticus strain ATCC BAA-2069 was sequenced and analyzed.
- Bioinformatic analysis predicted 2,309 open reading frames and identified a novel plasmid pSGG1.
- Significant differences were found when comparing the genomes of strains BAA-2069 and UCN34.
Takeaway
Scientists studied a germ that can cause heart infections and found new genes that help it stick to cells and resist antibiotics.
Methodology
The genome was sequenced using pyrosequencing and analyzed for open reading frames, plasmids, and comparative genomics.
Limitations
The study primarily focuses on one strain and may not represent the full diversity of the species.
Digital Object Identifier (DOI)
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