MMP8 Polymorphism and Lung Cancer Risk
Author Information
Author(s): González-Arriaga Patricia, López-Cima M Felicitas, Fernández-Somoano Ana, Pascual Teresa, Marrón Manuel G, Puente Xose S, Tardón Adonina
Primary Institution: Universidad de Oviedo
Hypothesis
Polymorphisms in MMP genes may influence the risk and survival of lung cancer patients.
Conclusion
The polymorphism in MMP8 is associated with a decreased lung cancer risk.
Supporting Evidence
- The MMP8 +17 C/G polymorphism was associated with a statistically significant decreased risk of developing lung cancer.
- Individuals with the G variant allele had a lower susceptibility to lung cancer.
- The study included a large sample size of 501 cases and 510 controls.
Takeaway
Some people have a gene change that helps protect them from lung cancer, while others do not.
Methodology
A hospital-based case-control study with 501 lung cancer patients and 510 matched controls, using PCR-RFLP for genotyping.
Potential Biases
Potential recall bias from retrospective data collection on smoking exposure.
Limitations
The study is hospital-based, which may introduce selection bias, and there is a risk of false positives due to multiple comparisons.
Participant Demographics
Caucasian population from Asturias, Northern Spain; 88% male and 12% female.
Statistical Information
P-Value
0.019
Confidence Interval
95% CI = 0.45–0.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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