Hepatoprotective Effects of Orthosiphon stamineus Extract on Liver Cirrhosis in Rats
Author Information
Author(s): Alshawsh Mohammed A., Abdulla Mahmood Ameen, Ismail Salmah, Amin Zahra A.
Primary Institution: University of Malaya
Hypothesis
The study aims to evaluate the hepatoprotective effects of Orthosiphon stamineus extract in a thioacetamide-induced liver cirrhosis model in rats.
Conclusion
The study found that 200 mg/kg of Orthosiphon stamineus extract significantly restored liver function and structure in rats with thioacetamide-induced liver damage.
Supporting Evidence
- The high-dose treatment group (200 mg/kg) significantly restored elevated liver function enzymes near to normal.
- Histopathological examination showed good recovery of thioacetamide-induced necrosis by ethanolic extracts.
- Treatment with O. stamineus extracts significantly reduced liver function biomarkers compared to the control group.
Takeaway
This study shows that a plant called Orthosiphon stamineus can help protect the liver from damage caused by a harmful chemical in rats.
Methodology
The study used a thioacetamide-induced hepatotoxic model in Sprague Dawley rats, with groups receiving different treatments over 60 days.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Adult male Sprague Dawley rats weighing 200–250 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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