Genome-wide expression profiling of spore germination in Saccharomyces cerevisiae reveals two major stages and identifies germination-specific regulation of cell cycle machinery.
2007
Gene Expression Patterns During Yeast Spore Germination
publication
Evidence: high
Author Information
Author(s): Joseph-Strauss Daphna, Zenvirth Drora, Simchen Giora, Barkai Naama
Primary Institution: Weizmann Institute of Science
Hypothesis
What are the global gene expression changes during spore germination in Saccharomyces cerevisiae?
Conclusion
The study identifies two major stages in spore germination and reveals specific regulation of cell cycle machinery during this process.
Supporting Evidence
- The germination process can be divided into two distinct stages.
- During the first stage, spores respond only to glucose.
- The second phase allows cells to sense and respond to other nutrients.
- Components of the mitotic machinery are involved in spore germination but are regulated differently than in the mitotic cell cycle.
Takeaway
When yeast spores wake up and start to grow, they go through two main stages, first responding to sugar and then to other nutrients.
Methodology
The study used genome-wide expression profiling and followed cell-cycle and germination markers during spore germination.
Digital Object Identifier (DOI)
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