Activin B Signals Through ALK7 in Gonadotrope Cells
Author Information
Author(s): Bernard Daniel J, Lee Katharine B, Santos Michelle M
Primary Institution: Center for Biomedical Research, Population Council and The Rockefeller University
Hypothesis
Can activin B signal through ALK7 to regulate Fshb transcription in gonadotrope cells?
Conclusion
Activin B can signal through ALK7 to stimulate Fshb transcription in gonadotropes.
Supporting Evidence
- ALK7 mRNA was expressed in gonadotrope cells and pituitary gland.
- Transfection of ALK4 enhanced the effects of both activin A and B on Fshb transcription.
- ALK7 selectively potentiated the effects of activin B.
Takeaway
This study shows that a protein called activin B can use a specific receptor, ALK7, to help produce a hormone in certain cells in the pituitary gland.
Methodology
The study involved transfecting gonadotrope cells with different forms of ALK4 and ALK7 and measuring their effects on Fshb transcription.
Limitations
The physiological role of ALK7 in FSH synthesis remains to be determined.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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