Selectivity and potency; are we doing the right things to find anti-cancer agents with these properties?
1992
Finding Better Anti-Cancer Agents
Editorial
Author Information
Author(s): J.A. Double
Primary Institution: University of Bradford
Hypothesis
Are we doing the right things to find anti-cancer agents with selectivity and potency?
Conclusion
The current methods for developing anti-cancer drugs may not be effectively identifying agents with the desired properties.
Supporting Evidence
- Many anti-cancer agents identified in murine leukaemias show limited clinical activity.
- Solid tumors are more resistant to standard treatments than leukaemias.
- New screening programs are based on in vitro sensitivity using human tumor cell lines.
Takeaway
Scientists are trying to find better medicines to fight cancer, but they might not be using the best tests to find the right ones.
Limitations
Current model systems may not accurately reflect human cancer, leading to ineffective drug development.
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