Increased Arterial Stiffness in Healthy People with High-Normal Glucose Levels
Author Information
Author(s): Shin Jin Young, Lee Hye Ree, Lee Duk Chul
Primary Institution: Gangnam Severance Hospital, Yonsei University College of Medicine
Hypothesis
Is there a relationship between fasting plasma glucose levels and arterial stiffness in non-diabetic healthy subjects?
Conclusion
Higher fasting plasma glucose levels, even within the normal range, are linked to increased arterial stiffness.
Supporting Evidence
- FPG has a positive association with arterial stiffness in non-diabetic subjects.
- The mean ba-PWV of the high-normal glucose group was higher than that of the low-normal glucose group.
- The mean ba-PWV value in the IFG group was higher than that in the normoglycemic group.
Takeaway
If your blood sugar is a little high but not diabetic, it can still make your blood vessels stiffer, which isn't good for your heart.
Methodology
The study involved 697 non-diabetic subjects who were assessed for fasting plasma glucose and arterial stiffness using brachial-ankle pulse wave velocity.
Potential Biases
Potential bias due to exclusion of subjects with low fasting plasma glucose levels and not accounting for insulin resistance.
Limitations
The study was cross-sectional and conducted in a single location, limiting generalizability.
Participant Demographics
Adults aged 20 to 79 years, mean age 52.3 years.
Statistical Information
P-Value
<0.01
Confidence Interval
1.40 (0.26, 2.55)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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