Revising the Unitary Model of Osteoporosis
Author Information
Author(s): Sundeep Khosla, Melton L. Joseph III, Riggs B. Lawrence
Primary Institution: Endocrine Research Unit, College of Medicine, Mayo Clinic
Hypothesis
Is a revision needed for the unitary model of osteoporosis considering new data?
Conclusion
The original model of osteoporosis requires modification but not complete revision, as estrogen deficiency remains a key factor for cortical bone loss.
Supporting Evidence
- New imaging techniques have improved our understanding of bone loss patterns.
- Trabecular bone loss begins in young adults, while cortical bone loss is linked to menopause.
- Estrogen deficiency is a major cause of bone loss in postmenopausal women.
Takeaway
This study looks at how bone loss happens as we age, especially in women after menopause, and suggests that while estrogen is important, other factors also play a role.
Methodology
The study reviews existing literature and data from clinical and animal studies to assess the role of estrogen in bone loss.
Limitations
The study primarily relies on existing data and may not account for all variables affecting bone loss.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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