Role of IL-33 in inflammation and disease
2011
Role of IL-33 in Inflammation and Disease
publication
Evidence: moderate
Author Information
Author(s): Miller Ashley M
Primary Institution: University of Glasgow
Hypothesis
IL-33 plays a dual role in inflammation, acting as both a pro-inflammatory and anti-inflammatory cytokine depending on the disease context.
Conclusion
IL-33 is a crucial cytokine that can either promote inflammation or provide protective effects in various diseases.
Supporting Evidence
- IL-33 is expressed by stromal cells and its levels increase during inflammation.
- IL-33 can activate T helper 2 cells, leading to increased production of Th2 cytokines.
- IL-33 has protective effects in cardiovascular diseases like atherosclerosis and obesity.
Takeaway
IL-33 is like a helper in our body that can either cause problems or help fix them, depending on the situation.
Methodology
This review discusses the role of IL-33 in various diseases, emphasizing recent advances in understanding its functions.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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