Coffee and Liver Cancer Risk
Author Information
Author(s): Gallus S, Bertuzzi M, Tavani A, Bosetti C, Negri E, La Vecchia C, Lagiou P, Trichopoulos D
Primary Institution: Istituto di Ricerche Farmacologiche ‘Mario Negri’
Hypothesis
Does coffee protect against hepatocellular carcinoma?
Conclusion
The study suggests that coffee consumption is inversely related to the risk of liver cancer.
Supporting Evidence
- The odds ratio for coffee drinkers was 0.8 compared to non-drinkers.
- For those drinking three or more cups per day, the odds ratio was 0.6.
- The inverse relation was consistent across both Italian and Greek datasets.
Takeaway
Drinking coffee might help lower the chances of getting liver cancer.
Methodology
The study analyzed data from two case-control studies in Italy and Greece, including 834 cases and 1912 controls.
Potential Biases
Possible differences in coffee consumption between hospital controls and the general population.
Limitations
The study may have biases due to the selection of hospital controls and reliance on self-reported data.
Participant Demographics
Cases included 501 subjects from Italy and 333 from Greece, with a median age of 60 and 65 years respectively.
Statistical Information
P-Value
<0.001
Confidence Interval
0.6–1.0
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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