A role for chromosomal instability in the development of and selection for radioresistant cell variants
2001
Chromosomal Instability and Radioresistance in Cancer Cells
Sample size: 30
publication
Author Information
Author(s): Limoli C L, Corcoran J J, Jordan R, Morgan W F, Schwartz J L
Primary Institution: Department of Radiation Oncology, University of California, San Francisco, CA
Hypothesis
Does the elevated rate of mutation formation in unstable cells lead to the development of clones of cells that are resistant to cancer therapy?
Conclusion
Chromosomal instability in GM10115 cells can lead to the development of cell variants that are more resistant to radiation.
Supporting Evidence
- There was a broader distribution of radiosensitivity in chromosomally unstable clones.
- The more radioresistant clones had significantly lower plating efficiencies.
Takeaway
Some cancer cells can change and become stronger against treatments like radiation because of their unstable chromosomes.
Methodology
Compared chromosome instability to radiation sensitivity in 30 independently isolated clones of GM10115 human–hamster hybrid cells.
Digital Object Identifier (DOI)
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