The Role of Tregs in Immune Reconstitution Inflammatory Syndrome in HIV
Author Information
Author(s): Shankar Esaki Muthu, Vignesh Ramachandran, Velu Vijayakumar, Murugavel Kailapuri G, Sekar Ramalingam, Balakrishnan Pachamuthu, Lloyd Charmaine AC, Saravanan Shanmugam, Solomon Suniti, Kumarasamy Nagalingeswaran
Primary Institution: YRG Centre for AIDS Research and Education
Hypothesis
Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease?
Conclusion
The study proposes that IRIS non-developers generate high avidity precursor T-cells to produce Tregs, while IRIS developers generate intermediate avidity T-cells leading to inflammation.
Supporting Evidence
- IRIS is believed to result from restored immunity to specific antigens.
- Subjects that develop IRIS have a high burden of proinflammatory cytokines.
- Treg cells are critical in regulating inflammatory responses.
- IL-10 Tregs limit immune responses against microbial antigens.
- Memory T-cells play a role in the immune response after HAART initiation.
Takeaway
Some people with HIV get worse after starting treatment because their immune system reacts too strongly. This study looks at how certain immune cells might help prevent that.
Limitations
The study acknowledges limitations in defining Treg populations and the challenges in measuring their frequency in HIV infection.
Digital Object Identifier (DOI)
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