Low Platelet-to-Lymphocyte Ratio Linked to Higher Death Rates in Trauma Patients
Author Information
Author(s): Kang-Wei To, Hsu Shiun-Yuan, Yu Chia-Ying, Tsai Yu-Chin, Lin You-Cheng, Hsieh Ching-Hua
Primary Institution: Chang Gung Memorial Hospital
Hypothesis
This study aimed to examine the association between the ratio of platelets to WBC subtypes and mortality outcomes in patients with moderate-to-severe traumatic brain injury (TBI).
Conclusion
Lower PLR is associated with greater mortality in adult patients with moderate-to-severe TBI.
Supporting Evidence
- The PLR of deceased patients was significantly lower than that of survivors.
- A lower PLR was recognized as an independent risk factor for mortality.
- Kaplan-Meier analysis showed significantly worse survival in the lowest PLR quartile group compared to the highest quartile group.
Takeaway
If a patient has a low platelet-to-lymphocyte ratio, they might be at a higher risk of dying after a serious brain injury.
Methodology
The study reviewed medical records of 2397 adult patients with moderate-to-severe TBI and analyzed the relationship between PLR and mortality outcomes using logistic regression and survival analysis.
Potential Biases
Potential selection bias due to exclusion of cases with incomplete data.
Limitations
The retrospective design may introduce selection bias, and the study did not include patients who died immediately upon arrival at the emergency room.
Participant Demographics
Adult trauma patients aged 20 years and older with moderate-to-severe TBI.
Statistical Information
P-Value
p=0.010
Confidence Interval
1.06–1.51
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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