Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
1999
Necrosis and Blood Vessel Density in Breast Cancer
Sample size: 109
publication
Evidence: moderate
Author Information
Author(s): Leek R D, Landers R J, Harris A L, Lewis C E
Primary Institution: ICRF Molecular Oncology Laboratory, University of Oxford
Hypothesis
Does necrosis in breast tumors correlate with vascular density and macrophage infiltration?
Conclusion
The study found that necrosis in breast tumors is associated with high vascular density and macrophage infiltration.
Supporting Evidence
- Necrosis is linked to poor prognosis in breast cancer.
- High focal macrophage infiltration is associated with increased tumor angiogenesis.
- Aggressive tumors often outgrow their blood supply, leading to necrosis.
Takeaway
In breast cancer, areas of dead tissue are linked to more blood vessels and immune cells, which might make the cancer worse.
Methodology
The study quantified necrosis, macrophage infiltration, and angiogenesis in 109 invasive breast carcinomas.
Statistical Information
P-Value
0.0009; 0.01; 0.0008; 0.03; < 0.001; 0.003; 0.008; < 0.008
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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