Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth
2001
Combining VEGF Inhibitor with Radiation to Fight Cancer
publication
Evidence: moderate
Author Information
Author(s): Hess C, Vuong V, Hegyi I, Riesterer O, Wood J, Fabbro D, Glanzmann C, Bodis S, Pruschy M
Primary Institution: University Hospital Zurich
Hypothesis
Does the combination of the VEGF receptor inhibitor PTK787/ZK222584 and ionizing radiation enhance the treatment of tumors?
Conclusion
The combination of PTK787/ZK222584 and ionizing radiation significantly delays tumor growth and reduces microvessel formation in resistant tumors.
Supporting Evidence
- The combination treatment significantly delayed tumor growth in resistant tumor models.
- Endothelial cell proliferation was inhibited without inducing apoptosis.
- The treatment reduced the number of microvessels in the tumor xenografts.
Takeaway
Using a special cancer drug together with radiation can help slow down tumor growth better than using either one alone.
Methodology
The study involved in vitro tests on endothelial cells and in vivo tests on tumor xenografts using a specific treatment regimen.
Digital Object Identifier (DOI)
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