Risk of physical health comorbidities in autistic adults: clinical nested cross-sectional study
2024

Health Risks in Autistic Adults

Sample size: 3594 publication 10 minutes Evidence: high

Author Information

Author(s): Hunt Megan, Underwood Jack F. G., Hubbard Leon, Hall Jeremy

Primary Institution: Neuroscience & Mental Health Innovation Institute, Cardiff University, UK

Hypothesis

Are physical health comorbidities more prevalent in autistic adults compared to non-autistic individuals?

Conclusion

Autistic adults are at a higher risk for various physical health conditions, especially those with concurrent intellectual disabilities.

Supporting Evidence

  • Individuals with autism showed significantly higher rates of asthma, epilepsy, and head injuries compared to controls.
  • Odds ratios for liver disease and osteoporosis were notably high in the autism group.
  • Conditions like hypertension and elevated lipids were also more prevalent in autistic individuals.

Takeaway

People with autism often have more health problems than those without autism, and this is even more true for those who also have learning disabilities.

Methodology

A nested cross-sectional study using data from the National Centre for Mental Health database, comparing 813 autistic individuals with 2781 controls.

Potential Biases

Potential biases due to self-selection and ascertainment from healthcare settings.

Limitations

The study relied on self-reported diagnoses and had missing data for some health conditions, which may affect reliability.

Participant Demographics

The autism group had a mean age of 33.73 years, with 41.9% female and 53.3% male participants.

Statistical Information

P-Value

p<0.001

Confidence Interval

95% CI for liver disease 4.36–30.60

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1192/bjo.2024.777

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