Factors Predicting Kidney Disease in Lupus Patients
Author Information
Author(s): Alarcón Graciela S, McGwin Gerald Jr., Petri Michelle, Ramsey-Goldman Rosalind, Fessler Barri J, Vilá Luis M, Edberg Jeffrey C, Reveille John D, Kimberly Robert P
Primary Institution: University of Alabama at Birmingham
Hypothesis
What factors predict the development of renal involvement and its progression to end-stage renal disease in a multi-ethnic lupus cohort?
Conclusion
The Fcγ receptor genotype is a risk factor for the progression of renal disease to end-stage renal disease, but does not explain the ethnic disparities in renal disease progression.
Supporting Evidence
- Patients developing renal involvement were more likely to be younger and hypertensive.
- African-American and Texan Hispanic individuals were more likely to develop kidney involvement.
- FCGR3A*GG genotype was associated with a higher risk of developing ESRD.
- Patients with renal involvement had a greater number of ACR criteria.
- Unemployment and lower education levels were linked to kidney problems in lupus patients.
Takeaway
This study looked at why some people with lupus get kidney problems. It found that younger people and certain ethnic groups are more likely to have these issues.
Methodology
The study used univariable and multivariable Cox proportional hazards regression analyses to examine factors associated with renal involvement and ESRD.
Potential Biases
Potential biases include the lack of standardization in treatment protocols and the exclusion of certain patient data.
Limitations
The study may not be representative of the overall lupus population as patients were recruited from academic health centers.
Participant Demographics
Participants included SLE patients from various ethnic backgrounds, including African-American, Texan Hispanic, Puerto Rican Hispanic, and White Americans.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 0.962–0.988
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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