Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men

2006

Mutations in the DAZL Gene and Infertility

Sample size: 519 publication Evidence: moderate

Author Information

Author(s): Tung Joyce Y, Rosen Mitchell P, Nelson Lawrence M, Turek Paul J, Witte John S, Cramer Daniel W, Cedars Marcelle I, Reijo-Pera Renee A

Primary Institution: University of California at San Francisco

Mutations in the DAZL gene could impact measures of germ cell numbers in men and women, namely sperm count and age at menopause.

The identified mutations in the DAZL gene may be associated with age at menopause and sperm count, indicating a need for further investigation.

Four putative missense mutations in the DAZL gene were identified.
Three individuals with a DAZL mutation had children, while two homozygous individuals did not.
The mutations were found only in infertile men and women.

Some people have changes in a gene called DAZL that might make it harder for them to have babies as they get older.

The DAZL gene was sequenced in 519 individuals to identify rare mutations and examine their phenotypes.

The study did not include a control group of individuals with normal fertility to compare the mutations.

The study included men and women with infertility issues, with specific age ranges for women experiencing premature ovarian failure.

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