Hypochlorous Acid for Wound Care
Author Information
Author(s): Robson Martin C. MD, Payne Wyatt G. MD, Ko Francis B. Sa, Mentis Marni D. O., Donati Guillermo DPM, Shafii Susan M. MD, Culverhouse Susan M. D., Wang Lu PhD, Khosrovi Behzad PhD, Najafi Ramin PhD, Cooper Diane M. PhD, Bassiri Mansour PhD
Primary Institution: Institute for Tissue Regeneration, Repair and Rehabilitation, Bay Pines, FL
Hypothesis
Can stabilized hypochlorous acid (NVC-101) effectively decrease tissue bacterial bioburden and promote wound healing?
Conclusion
NVC-101 is effective in controlling bacterial bioburden without inhibiting wound healing.
Supporting Evidence
- NVC-101 at 0.01% was effective in reducing bacterial counts.
- NVC-101 was more effective at pH 3.5 or 4.0.
- Short applications of NVC-101 followed by wiping improved bacterial reduction.
- Silvadene was the most effective at decreasing bacterial burden but less effective at promoting wound closure.
Takeaway
This study tested a special liquid that can kill germs in wounds without stopping them from healing.
Methodology
The study used a rodent model with chronic infected wounds to test various concentrations and pH levels of NVC-101.
Limitations
The requirement to maintain a narrow pH range in clinical settings may limit its application.
Participant Demographics
Male Sprague-Dawley rats weighing 300 to 350 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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