Healthy Lifestyle Reduces Obesity Risk in People with High Genetic Risk
Author Information
Author(s): Sutoh Yoichi, Hachiya Tsuyoshi, Otsuka-Yamasaki Yayoi, Komaki Shohei, Minabe Shiori, Ohmomo Hideki, Sasaki Makoto, Shimizu Atsushi
Primary Institution: Iwate Medical University
Hypothesis
To what extent can an individual with a high polygenic score for obesity improve outcomes through lifestyle modifications?
Conclusion
Adopting healthy lifestyles can significantly reduce obesity risk, even in individuals with a high genetic predisposition to obesity.
Supporting Evidence
- Individuals with high polygenic scores for obesity showed significantly higher obesity risks.
- Increased leisure-time physical activity was associated with reduced obesity risk across all genetic risk categories.
- Sodium intake was positively associated with obesity risk in individuals with high genetic risk.
Takeaway
Eating healthy and being active can help people who are more likely to be overweight because of their genes.
Methodology
The study used four datasets from the Tohoku Medical Megabank Community-Based Cohort to assess the impact of lifestyle modifications on obesity risk.
Potential Biases
Potential unmeasured biases related to the geographical restriction of the cohort.
Limitations
The study is based on a community cohort from a specific geographical area, which may limit the generalizability of the results.
Participant Demographics
The study included a diverse population from Japan, with a significant percentage of female participants.
Statistical Information
P-Value
0.9859
Confidence Interval
[95% CI: 2.12–2.44]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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