D-Chiro-Inositol - Its Functional Role in Insulin Action and Its Deficit in Insulin Resistance
2002
D-Chiro-Inositol and Its Role in Insulin Action
publication
Evidence: moderate
Author Information
Author(s): JOSEPH LARNER, M.D., PH.D.
Primary Institution: University of Virginia School of Medicine
Hypothesis
D-chiro-inositol may help restore insulin sensitivity and glucose disposal in insulin-resistant individuals.
Conclusion
D-chiro-inositol administration can improve insulin sensitivity and glucose disposal in diabetic models.
Supporting Evidence
- Administration of D-chiro-inositol to diabetic rats and humans accelerated glucose disposal.
- Decreased urinary excretion of chiro-inositol is associated with insulin resistance.
- Altered ratios of myo-inositol to chiro-inositol in urine may indicate insulin resistance.
Takeaway
D-chiro-inositol is a substance that helps the body use insulin better, which is important for people with diabetes.
Methodology
The review discusses various studies on D-chiro-inositol's effects on insulin action and its relationship with insulin resistance.
Limitations
The review is based on existing studies and may not include all recent findings.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website