Modulation of NKT Cell Development by B7-CD28 Interaction: An Expanding Horizon for Costimulation
2008
B7-CD28 Interaction and NKT Cell Development
Sample size: 9
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Zheng Xincheng, Zhang Huiming, Yin Lijie, Wang Chyung-Ru, Liu Yang, Zheng Pan
Primary Institution: University of Michigan
Hypothesis
The B7-CD28 interaction is involved in the development of NKT cells.
Conclusion
The study shows that B7-CD28 interaction is crucial for the development, maturation, and function of NKT cells.
Supporting Evidence
- The study demonstrated that NKT cell development is significantly reduced in B7-1/2 and CD28 deficient mice.
- Decreased cell proliferation was observed in the absence of B7-CD28 interaction.
- NKT cells in B7-1/2 deficient mice showed reduced susceptibility to Con A induced hepatitis.
Takeaway
This study found that certain signals help special immune cells called NKT cells grow and work better, which is important for fighting infections.
Methodology
The study compared NKT cell development in wild-type mice and mice with mutations in B7-1/2 and CD28.
Participant Demographics
Mice used in the study were age and sex-matched.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website