p73 Polymorphism and Oesophageal Cancer Risk
Author Information
Author(s): Ryan B M, McManus R, Daly J S, Carton E, Keeling P W N, Reynolds J V, Kelleher D
Primary Institution: Departments of Clinical Medicine and Gastroenterology, Surgery, St. James's Hospital and Trinity College, Dublin 8, Ireland
Hypothesis
Does a common p73 polymorphism influence the incidence of oesophageal carcinoma?
Conclusion
p73 AT/AT homozygotes are significantly less likely to develop oesophageal cancer.
Supporting Evidence
- AT/AT homozygotes were significantly less prevalent in the oesophageal cancer population compared to controls.
- The odds ratio for AT/AT homozygotes was 0.11, indicating a 9-fold reduced risk.
- LOH at the p73 locus was observed in 37.8% of the AT/GC heterozygotes studied.
Takeaway
Some people have a special gene that makes them less likely to get a certain type of throat cancer.
Methodology
This was a case–control, retrospective study involving genotyping of cancer cases and normal controls.
Participant Demographics
84 cases of oesophageal cancer and 152 normal population controls.
Statistical Information
P-Value
P < 0.02
Confidence Interval
95% C.I. 0.02–0.6
Statistical Significance
p<0.02
Digital Object Identifier (DOI)
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