Negative regulation by nuclear receptors: a plethora of mechanisms
2011
Understanding How Nuclear Receptors Regulate Gene Expression
publication
Evidence: high
Author Information
Author(s): Santos Guilherme M., Fairall Louise, Schwabe John W.R.
Hypothesis
How do ligand-bound nuclear receptors repress transcription of certain genes?
Conclusion
Nuclear receptors can repress gene transcription through various complex mechanisms, including the recruitment of corepressors and competition with other transcription factors.
Supporting Evidence
- Nuclear receptors can activate or repress transcription depending on whether they are bound to a ligand.
- Corepressors and coactivators can bind to the same nuclear receptors, but their binding is mutually exclusive.
- Ligand-bound nuclear receptors can block transcriptional activation by competing with other transcription factors.
Takeaway
Nuclear receptors are like switches that can turn genes on or off, and they can do this in different ways depending on whether they have a special key (ligand) or not.
Digital Object Identifier (DOI)
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