1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one monohydrate C28H24N4O4·H2O
2011
Crystal Structure of a New Quinoline-Isoxazole Compound
publication
Evidence: moderate
Author Information
Author(s): Gutierrez Margarita, Vallejos Gabriel, Fernández Carlos, Cárdenas Alejandro, Brito Iván
Primary Institution: Instituto de Química de Recursos Naturales, Universidad de Talca, Chile
Conclusion
The study presents the crystal structure of a novel synthetic derivative of quinoline-isoxazole, revealing significant torsion angles and hydrogen bonding interactions.
Supporting Evidence
- The compound crystallizes with two organic molecules and two water molecules in the asymmetric unit.
- Significant torsion angles were observed between the isoxazole and phenyl rings.
- Intramolecular hydrogen bonds stabilize the molecular conformation.
Takeaway
Scientists created a new compound by combining two chemical structures, and they figured out how it looks in a crystal form.
Methodology
The compound was synthesized through an imino Diels-Alder cycloaddition reaction and characterized using X-ray crystallography.
Digital Object Identifier (DOI)
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