pi-Turns: types, systematics and the context of their occurrence in protein structures
2008
Understanding π-Turns in Protein Structures
Sample size: 1608
publication
Evidence: moderate
Author Information
Author(s): Bhaskar Dasgupta, Pinak Chakrabarti
Primary Institution: Bose Institute, Calcutta, India
Hypothesis
A systematic characterization of π-turns will provide valuable insights into their structural roles in proteins.
Conclusion
The study identifies and classifies π-turns, revealing their significant roles in protein structure and function.
Supporting Evidence
- At least 20% of π-turns occur independent of the Schellman motif.
- 597 hydrogen-bonded π-turns were identified.
- The majority of π-HB turns are in AAAa conformation.
Takeaway
This study looks at special shapes in proteins called π-turns, which help proteins keep their shape and do their jobs.
Methodology
The study analyzed protein structures from the Protein Data Bank, identifying π-turns based on hydrogen bonding and backbone torsion angles.
Limitations
The study may not cover all possible π-turn configurations due to the limitations of the dataset used.
Digital Object Identifier (DOI)
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