The Role of Left Ventricular Subendocardial Involvement in Autoimmune Rheumatic Disease
Author Information
Author(s): Danni Wu, Xiao Li, Tianchen Guo, Xiaojin Feng, Xinhao Li, Yining Wang, Wei Chen
Primary Institution: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Hypothesis
LV LGEse is associated with a greater incidence of adverse cardiac outcomes in ARD patients.
Conclusion
In our cohort, LV subendocardial involvement, an underrecognized LGE pattern, was observed in 13% of all patients with autoimmune disease and indicated a worse prognosis.
Supporting Evidence
- LV LGEse was observed in 13% of all autoimmune disease patients with clinically suspected cardiac involvement.
- During a median follow‐up of 776 days, 20 patients experienced a composite endpoint.
- The LV LGEse group had a greater proportion of men (64% vs. 14%).
- The LV LGEse group had a lower LV ejection fraction (50% vs. 60%).
- The LV LGEse group had a greater LV end‐diastolic volume index (78 vs. 75).
- The LV LGEse group had more adverse outcomes (32% vs. 8%).
- Univariable Cox regression analysis confirmed that LV LGEse was a significant predictor of the composite endpoint.
Takeaway
This study found that a specific heart issue in autoimmune disease patients can lead to more serious health problems.
Methodology
This retrospective study evaluated 176 patients diagnosed with ARD with clinically suspected cardiac involvement between 2018 and 2023.
Potential Biases
The study was retrospective, which may introduce selection bias.
Limitations
The number of patients was small, and the study included various types of ARDs, which may affect the generalizability of the findings.
Participant Demographics
The cohort included 176 ARD patients, with a median age of 39 years and 140 women.
Statistical Information
P-Value
p<0.001
Confidence Interval
1.94–12.37
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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