The Role of REV-ERBα and β in Circadian Rhythms
Author Information
Author(s): Liu Andrew C., Tran Hien G., Zhang Eric E., Priest Aaron A., Welsh David K., Kay Steve A.
Primary Institution: University of California San Diego
Hypothesis
REV-ERBα and β are functionally redundant and required for rhythmic Bmal1 expression.
Conclusion
REV-ERBα and β are essential for maintaining Bmal1 rhythmicity, while RORs are not necessary for this function.
Supporting Evidence
- REV-ERBα and β are required for rhythmic Bmal1 expression.
- RORs contribute to Bmal1 amplitude but are dispensable for Bmal1 rhythm.
- Cells deficient in both REV-ERBα and β function can still generate normal Per2 rhythmicity.
Takeaway
This study shows that two proteins, REV-ERBα and β, help keep our body's internal clock working properly, while another group of proteins, RORs, are not needed for this.
Methodology
The study used gene knockout and RNA interference techniques to analyze circadian oscillations in cells.
Limitations
The study may not fully account for the complex interactions of all circadian components in vivo.
Digital Object Identifier (DOI)
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