HPV Infection in HIV-Positive Men Who Have Sex with Men
Author Information
Author(s): Parisi Saverio G, Cruciani Mario, Scaggiante Renzo, Boldrin Caterina, Andreis Samantha, Bello Federico Dal, Pagni Silvana, Barelli Andrea, Sattin Andrea, Mengoli Carlo, Palù Giorgio
Primary Institution: Department of Histology, Microbiology and Medical Biotechnology, Padua University
Hypothesis
What is the frequency and persistence of concurrent oral and anal HPV infections in HIV-infected MSM over a 6-month period?
Conclusion
A high prevalence of HPV infection was found in HIV-infected MSM, with a negative correlation between anal HPV infection and CD4 cell count.
Supporting Evidence
- The overall prevalence of HPV did not vary significantly between baseline and follow-up.
- 75% of patients with HPV at baseline had persistent infections after 6 months.
- HPV prevalence was higher in younger patients, particularly in the 43-50 age group.
- HHV-8 oral shedding was positively related to HPV anal infection.
Takeaway
The study found that many HIV-positive men who have sex with men have HPV infections in their mouths and anuses, and these infections can stick around for a long time.
Methodology
The study used PCR to detect HPV from oral and anal swabs collected at baseline and 6 months later from HIV-positive MSM.
Potential Biases
Potential bias due to missing data from inadequate samples.
Limitations
The study had a number of subjects with inadequate samples and did not fully characterize co-infections.
Participant Demographics
HIV-positive men who have sex with men, mean age 43.8 years.
Statistical Information
P-Value
0.0046
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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