Study of SNPs in Folate Metabolism in Healthy Indians
Author Information
Author(s): Ghodke Yogita, Chopra Arvind, Shintre Pooja, Puranik Amrutesh, Joshi Kalpana, Patwardhan Bhushan
Primary Institution: Interdisciplinary School of Health Sciences (ISHS), University of Pune, Pune, India
Hypothesis
The study aims to determine the allelic frequencies of SNPs in the folate biosynthetic pathway in an Indian ethnic population.
Conclusion
The study found significant differences in the distribution of folate metabolism SNPs among healthy Indians compared to other populations.
Supporting Evidence
- Allele frequencies for MTHFR 677T and 1298C were found to be 10% and 30%, respectively.
- The study validated previous findings of differences in SNP frequencies due to race and ethnicity.
- The results indicate that the distribution of SNPs in folate metabolism varies significantly among different populations.
Takeaway
This study looked at how common certain genetic variations are in healthy Indian people, which can help understand how these variations affect health and medicine.
Methodology
DNA was extracted from blood samples and genotyping was performed using PCR-RFLP and Real-time Taqman allelic discrimination for 12 polymorphisms in 9 genes.
Limitations
The study only analyzed 12 polymorphisms and did not include all relevant genes in folate metabolism.
Participant Demographics
70 males and 74 females with a mean age of 23.22 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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