VEGF Polymorphism and BI-RADS Scores in Breast Cancer
Author Information
Author(s): Wehrschuetz M., Schöllnast H., Wehrschuetz E., Renner W., Luschin G.
Primary Institution: Medical University Graz
Hypothesis
Is there an association between VEGF genotype and the radiological appearance of breast lesions?
Conclusion
The VEGF 936C > T polymorphism seems to be associated with a high BI-RADS score in women with suspicious breast lesions.
Supporting Evidence
- 79% of patients had the CC genotype, 17% had CT, and 4% had TT.
- Carriers of the TT genotype were classified as BI-RADS 5.
- Statistical significance was found in the association between VEGF polymorphism and BI-RADS scores.
Takeaway
This study found that a specific gene change in women might help doctors predict if a breast lump is more likely to be cancerous.
Methodology
The study analyzed 52 women with suspected breast lesions using mammography and determined their VEGF genotype.
Limitations
The study's small sample size limits the generalizability of the findings.
Participant Demographics
Women aged 30 to 82, mean age 54.5 years.
Statistical Information
P-Value
p<0.026
Statistical Significance
p<0.026
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