Genetic Variations in the GHRHR Gene and Their Impact on Height
Author Information
Author(s): Åsa Johansson, Inger Jonasson, Ulf Gyllensten, Peter Heutink
Primary Institution: Uppsala University
Hypothesis
Does the GHRHR gene affect normal variation in height?
Conclusion
The study found that specific haplotypes in the GHRHR gene are significantly associated with variations in height.
Supporting Evidence
- The GHRHR gene is linked to growth hormone regulation.
- Two haplotypes associated with height were identified in both study populations.
- The effect size of the GHRHR haplotypes is larger than previously identified genes affecting height.
Takeaway
Scientists looked at a gene that helps control growth and found that certain versions of this gene can make people taller or shorter.
Methodology
The study used whole genome linkage analysis and SNP association tests in two populations from northern Sweden.
Limitations
The study may not account for all genetic factors influencing height due to the complexity of height as a trait.
Participant Demographics
Participants were from the southern Swedish Sami population and an independent northern Swedish population.
Statistical Information
P-Value
0.00077
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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