Ciprofloxacin-Resistant Salmonella in China
Author Information
Author(s): Cui Shenghui, Li Jingyun, Sun Ziyong, Hu Changqin, Jin Shaohong, Guo Yunchang, Ran Lu, Ma Yue
Primary Institution: State Food and Drug Administration, Beijing, People’s Republic of China
Hypothesis
What are the characteristics of ciprofloxacin-resistant Salmonella enterica serotype Typhimurium isolates in Wuhan, China?
Conclusion
The study found a high incidence of ciprofloxacin-resistant Salmonella Typhimurium isolates among outpatients in Wuhan, China.
Supporting Evidence
- All 31 ciprofloxacin-resistant isolates were also resistant to more than 8 other antimicrobial drugs.
- The study identified mutations in GyrA and ParC associated with resistance.
- Ciprofloxacin-resistant isolates were grouped into distinct PFGE clusters.
Takeaway
Doctors found a lot of Salmonella germs that don't get better with a common medicine called ciprofloxacin in patients at a hospital in China.
Methodology
The study analyzed stool samples from outpatients and characterized Salmonella isolates using biochemical tests, antimicrobial susceptibility testing, and mutation analysis.
Potential Biases
Potential bias due to the study being conducted in a university-affiliated medical center that treats more severe cases.
Limitations
The study did not have patient antimicrobial drug-use information and was limited to a single hospital.
Participant Demographics
Outpatients from Tongji Hospital in Wuhan, China.
Digital Object Identifier (DOI)
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