Involvement of serotonin and eicosanoids in the rat paw oedema response to the essential oil of Pilocarpus spicatus
1992
Effects of Pilocarpus spicatus Essential Oil on Rat Paw Swelling
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): J. C. R. Silva, V. S. N. Rao
Primary Institution: Universidade Federal do Ceara
Hypothesis
Does Pilocarpus spicatus essential oil induce paw oedema in rats?
Conclusion
Pilocarpus spicatus essential oil induces a dose-dependent paw oedema in rats, with significant involvement of serotonin and eicosanoids.
Supporting Evidence
- Pilocarpus spicatus essential oil induced greater paw swelling than carrageenan at 1 hour post-injection.
- Serotonin antagonist methysergide significantly reduced paw oedema at 1 and 2 hours after PSEO injection.
- Dexamethasone showed the greatest potency in suppressing oedema caused by PSEO.
Takeaway
When rats were given a special oil, their paws swelled up, and this swelling was affected by certain medicines.
Methodology
Male Wistar rats were injected with Pilocarpus spicatus essential oil and paw swelling was measured at various time points.
Participant Demographics
Male Wistar rats, weighing 120-180 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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