Pathogenic Events of Newborn Mice Encephalitis Induced by Itacaiunas and Curionópolis Viruses
Author Information
Author(s): Diniz José Antonio Picanço, dos Santos Zaire Alves, Braga Marcio Augusto Galvão, Dias Ádila Liliane Barros, da Silva Daisy Elaine Andrade, Medeiros Daniele Barbosa de Almeida, Barros Vera Lucia Reis de Souza, Chiang Jannifer Oliveira, Zoghbi Kendra Eyllen de Freitas, Quaresma Juarez Antônio Simões, Takiya Christina Maeda, Moura Neto Vivaldo, de Souza Wanderley, Vasconcelos Pedro Fernando da Costa, Diniz Cristovam Wanderley Picanço
Primary Institution: Instituto Evandro Chagas, Belém, Brazil
Hypothesis
What are the cell targets and the sequence of neuroinvasion?
Conclusion
Curionopolis virus causes lethal encephalitis in newborn mice, while Itacaiunas virus leads to a subacute non-lethal infection in some cases.
Supporting Evidence
- Curionopolis virus caused 100% mortality in infected newborn mice between 5 and 6 days post-inoculation.
- Itacaiunas virus resulted in a 35% mortality rate between 8 and 15 days post-inoculation.
- Distinct neuropathological changes were observed between the two viruses.
- Immunolabeling revealed viral antigens in the olfactory pathways at 2 and 3 days post-inoculation.
- Clinical signs were first observed at 4 and 8 days post-inoculation for Curionopolis and Itacaiunas viruses, respectively.
Takeaway
This study looked at how two viruses affect baby mice's brains, showing that one virus can make them very sick and the other can sometimes just make them a little sick.
Methodology
The study involved intranasal and intracerebral inoculation of newborn mice with Itacaiunas and Curionopolis viruses, followed by observation of clinical signs and histopathological analysis.
Limitations
The study did not investigate the long-term effects of the infections on surviving mice.
Participant Demographics
Newborn albino Swiss mice were used in the experiments.
Digital Object Identifier (DOI)
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