Effects of Eprosartan on Metabolic Parameters in Hypertensive Patients
Author Information
Author(s): Rizos Evangelos C, Spyrou Athanasia, Liberopoulos Evangelos N, Papavasiliou Eleni C, Saougos Vasilis, Tselepis Alexandros D, Elisaf Moses
Primary Institution: University of Ioannina
Hypothesis
Does eprosartan have effects on metabolic parameters beyond its antihypertensive action?
Conclusion
Eprosartan primarily lowers blood pressure and has neutral effects on most metabolic parameters in hypertensive patients.
Supporting Evidence
- Eprosartan reduced systolic blood pressure by 8% and diastolic blood pressure by 13%.
- It increased the time needed to produce oxidative by-products by 24%.
- Eprosartan reduced aspartate aminotransferase by 14% and alanine aminotransferase by 21%.
- It had no effect on glucose homeostasis, creatinine, or uric acid levels.
- Eprosartan did not affect clotting or fibrinolytic activity.
Takeaway
Eprosartan helps lower blood pressure but doesn't change much else in the body for people with high blood pressure.
Methodology
An open-label intervention study with 40 adult patients with essential hypertension taking eprosartan.
Limitations
The study did not include a liver biopsy to diagnose non-alcoholic fatty liver disease.
Participant Demographics
40 Caucasian adults (19 females) with a mean age of 57 years, most were overweight, 17 had metabolic syndrome, 8 had type 2 diabetes, and 18 were smokers.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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