Deficient mismatch repair in advanced colorectal cancer
Author Information
Author(s): Koopman M, Kortman G A M, Mekenkamp L, Ligtenberg M J L, Hoogerbrugge N, Antonini N F, Punt C J A, van Krieken J H J M
Primary Institution: Radboud University Nijmegen Medical Centre
Hypothesis
What is the incidence and outcome of sporadic deficient mismatch repair in advanced colorectal cancer?
Conclusion
Deficient mismatch repair is rare in patients with sporadic advanced colorectal cancer.
Supporting Evidence
- Deficient mismatch repair was found in only 18 (3.5%) out of 515 evaluable patients.
- The median overall survival for proficient mismatch repair patients was 17.9 months.
- Patients with deficient mismatch repair caused by hypermethylation of the MLH1 promoter had a median overall survival of 7.4 months.
Takeaway
This study found that only a small number of patients with advanced colorectal cancer have a problem with their DNA repair system, which is usually linked to better outcomes in earlier stages.
Methodology
Data were collected from a phase III study involving 820 advanced colorectal cancer patients, examining mismatch repair protein expression and microsatellite instability.
Limitations
The low incidence of deficient mismatch repair does not allow for meaningful conclusions about treatment outcomes.
Participant Demographics
Median age of participants was 63 years, with a range from 31 to 81 years.
Statistical Information
Confidence Interval
95% CI 16.2–18.8 for overall survival in proficient mismatch repair patients.
Digital Object Identifier (DOI)
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