Resistance to Permethrin and DDT in Mosquitoes from Sudan
Author Information
Author(s): Himeidan Yousif E, Muzamil Hamid M Abdel, Jones Christopher M, Ranson Hilary
Primary Institution: University of Kassala, Sudan
Hypothesis
What is the extent of resistance to permethrin and DDT in Anopheles arabiensis populations from eastern and central Sudan?
Conclusion
The kdr allele contributes to resistance to permethrin and DDT in Sudan, but other resistance mechanisms are also present.
Supporting Evidence
- Three out of seven populations were resistant to permethrin.
- Five out of six populations were resistant to DDT.
- The 1014F kdr allele was present in all six populations tested.
- Resistance mechanisms other than kdr alleles are likely contributing to survival.
- High mortality rates were observed in some populations, indicating varying levels of resistance.
Takeaway
Some mosquitoes in Sudan are not dying from insecticides like permethrin and DDT because they have become resistant, and this is a big problem for controlling malaria.
Methodology
The study involved collecting mosquito larvae from various breeding sites and testing their resistance to permethrin and DDT using WHO protocols.
Potential Biases
Potential bias in sampling locations and methods could affect the generalizability of the findings.
Limitations
The study may not account for all resistance mechanisms present in the populations.
Participant Demographics
The study focused on Anopheles arabiensis populations from five states in eastern and central Sudan.
Statistical Information
P-Value
0.0460
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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