Ampicillin Resistance in Pregnant Women with Pyelonephritis
Author Information
Author(s): Laura G. Greer, Scott W. Roberts, Jeanne S. Sheffield, Vanessa L. Rogers, James B. Hill, Donald D. Mcintire, George D. Wendel Jr.
Primary Institution: University of Texas Southwestern Medical Center
Hypothesis
Does the presence of ampicillin-resistant uropathogens in acute antepartum pyelonephritis affect clinical outcomes in pregnant women?
Conclusion
Most uropathogens were ampicillin resistant, but there were no differences in clinical outcomes for patients with resistant organisms.
Supporting Evidence
- 51% of uropathogens were ampicillin resistant.
- Patients with ampicillin-resistant organisms did not have higher complication rates.
- 72% of cases had urine cultures with identification of organism and antibiotic sensitivities.
Takeaway
This study looked at pregnant women with a kidney infection and found that even though many germs were resistant to a common antibiotic, the patients did just as well as those with germs that weren't resistant.
Methodology
This was a secondary analysis of a prospective cohort study involving 440 pregnant women diagnosed with acute pyelonephritis.
Limitations
The study only included inpatients, and the findings may not apply to outpatients; also, antibiotic sensitivities were only performed on Gram-negative organisms.
Participant Demographics
The patients with ampicillin-resistant organisms were more likely to be older and multiparous.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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