Antibiotic-Induced Resistance in Pregnancy
Author Information
Author(s): Gilles R.G. Monif
Primary Institution: Creighton University School of Medicine
Hypothesis
Does the use of ampicillin during pregnancy lead to the emergence of antibiotic-resistant bacteria?
Conclusion
The use of ampicillin did not select for resistant organisms but changed the proportion of resistant to non-resistant isolates.
Supporting Evidence
- Three isolates were ampicillin-resistant E. coli.
- Two neonates died with perinatal septicemia.
- Approximately 35-40% of E. coli isolates are resistant to ampicillin.
Takeaway
Using antibiotics like ampicillin can change how many resistant germs we see, but it doesn't necessarily make new resistant germs appear.
Potential Biases
Potential bias in interpreting the impact of antibiotic use on resistance patterns.
Limitations
The report did not specify the time frame for case collection or the number of cases that would have been treated successfully with ampicillin.
Participant Demographics
Gravidas receiving ampicillin prophylaxis for premature rupture of membranes.
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