Timing of Stem Cell Transplantation Affects Survival in Lymphoma
Author Information
Author(s): Holtan Shernan G, Porrata Luis F, Inwards David J, Ansell Stephen M, Micallef Ivana N, Johnston Patrick B, Litzow Mark R, Gastineau Dennis A, Markovic Svetomir N
Primary Institution: Mayo Clinic College of Medicine
Hypothesis
The time interval from last chemotherapy to aphaeresis affects the preaphaeresis absolute lymphocyte count.
Conclusion
Longer time intervals from last chemotherapy to aphaeresis are associated with better survival outcomes in non-Hodgkin lymphoma patients undergoing autologous stem cell transplantation.
Supporting Evidence
- A strong correlation between TILC and PA-ALC was identified (r = 0.67, P < 0.0001).
- Higher PA-ALC was observed in TILC ≥55 d compared with TILC <55 d.
- Median overall survival was longer in the TILC ≥55 d group compared to the TILC <55 d group.
Takeaway
If patients wait longer after their last chemotherapy before getting their stem cells collected, they tend to do better after the transplant.
Methodology
This retrospective study evaluated 160 NHL patients who underwent ASCT, analyzing the correlation between the time from last chemotherapy and lymphocyte counts.
Potential Biases
No patients were lost to follow-up, but the study's retrospective nature may introduce selection bias.
Limitations
The study is retrospective and may be subject to biases inherent in such designs.
Participant Demographics
Median age was 54 years, with a range from 23 to 73 years.
Statistical Information
P-Value
P < 0.0001
Confidence Interval
95% CI not specified
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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