Study of Seocalcitol for Liver Cancer
Author Information
Author(s): Dalhoff K, Dancey J, Astrup L, Skovsgaard T, Hamberg K J, Lofts F J, Rosmorduc O, Erlinger S, Bach Hansen J, Steward W P, Skov T, Burcharth F, Evans T R J
Primary Institution: Rigshospitalet, Denmark
Hypothesis
Can the vitamin D analogue Seocalcitol show antitumour activity in patients with inoperable hepatocellular carcinoma?
Conclusion
Seocalcitol demonstrated some antitumour activity in advanced hepatocellular carcinoma, with two patients achieving complete responses.
Supporting Evidence
- Seocalcitol was well tolerated in a phase I clinical study.
- The study included 56 patients from multiple countries.
- Two patients achieved complete responses after treatment.
Takeaway
This study tested a vitamin D drug called Seocalcitol in patients with liver cancer that couldn't be surgically removed, and it helped some patients.
Methodology
This was a multicentre, open, noncontrolled trial involving patients with inoperable hepatocellular carcinoma who received Seocalcitol treatment.
Limitations
The study had a small sample size and a low overall response rate, making it difficult to draw definitive conclusions.
Participant Demographics
{"median_age":62.5,"gender_distribution":{"male":42,"female":14},"performance_status":{"0":26,"1":22,"2":7},"extent_of_disease":{"local":41,"metastatic":15}}
Digital Object Identifier (DOI)
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