ATM Variants and Breast Cancer Risk in Southern Finland
Author Information
Author(s): Tommiska Johanna, Jansen Laila, Kilpivaara Outi, Edvardsen Hege, Kristensen Vessela, Tamminen Anitta, Aittomäki Kristiina, Blomqvist Carl, Børresen-Dale Anne-Lise, Nevanlinna Heli
Primary Institution: Helsinki University Central Hospital
Hypothesis
Do ATM genetic variants contribute to breast cancer risk in Southern Finland?
Conclusion
The study suggests that ATM genetic variants have a very minor effect, if any, on familial breast cancer risk in Southern Finland.
Supporting Evidence
- Neither of the two common variants was significantly associated with breast cancer risk.
- The study included a large sample size of familial and unselected breast cancer cases.
- The results do not support the association of the studied variants with bilateral breast cancer.
Takeaway
The study looked at certain genetic changes to see if they make people more likely to get breast cancer, but found that they probably don't.
Methodology
The study involved genotyping two common ATM variants in 786 familial and 884 unselected breast cancer cases, along with 708 healthy controls.
Limitations
The study may not have had enough power to detect small increases in risk due to the sample size.
Participant Demographics
Participants included familial breast cancer patients and unselected breast cancer cases from Southern Finland.
Statistical Information
P-Value
p=0.02 for multiple primary cancers association
Confidence Interval
95% CI 1.23–5.35 for multiple primary cancers
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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