Limonene and 4-Hydroxyandrostenedione for Rat Mammary Tumours
Author Information
Author(s): S.K. Chander, A.G.B. Lansdown, Y.A. Luqmani, J.J. Gomm, R.C. Coope, N. Gould, R.C. Coombes
Primary Institution: Celttech Ltd and Charing Cross Hospital Medical School
Hypothesis
Can limonene combined with 4-hydroxyandrostenedione enhance the treatment of NMU-induced rat mammary tumours?
Conclusion
The combination of limonene and 4-hydroxyandrostenedione resulted in greater tumour regression than either treatment alone.
Supporting Evidence
- 10% limonene caused tumour regression in all treated rats.
- 5% limonene alone caused regression in 50% of rats.
- 4-hydroxyandrostenedione alone caused regression in 75% of rats.
- The combination of 5% limonene and 4-hydroxyandrostenedione resulted in 83.3% regression.
Takeaway
This study found that a natural compound called limonene, when mixed with another drug, can help shrink tumours in rats.
Methodology
In vivo studies with NMU-induced rat mammary tumours treated with limonene and 4-hydroxyandrostenedione for 4 weeks.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Inbred virgin female Ludwig/Wistar/Olac rats
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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