Testing the Quality of Tamiflu
Author Information
Author(s): Green Michael D., Nettey Henry, Wirtz Robert A.
Primary Institution: Centers for Disease Control and Prevention
Hypothesis
Can colorimetric and chromatographic methods effectively assess the authenticity of oseltamivir?
Conclusion
Both colorimetric and chromatographic methods showed that all tested batches of oseltamivir were within ±15% of the stated amount of active ingredient.
Supporting Evidence
- The colorimetric assay showed greater sensitivity and accuracy compared to the chromatographic method.
- All tested oseltamivir products were within ±15% of the stated active ingredient amount.
- Counterfeit Tamiflu products have been found to contain no active ingredient.
Takeaway
The study created simple tests to check if Tamiflu is real or fake, helping to ensure people get the right medicine.
Methodology
The study developed and evaluated colorimetric and high-performance liquid chromatographic methods to measure oseltamivir in pharmaceutical preparations.
Limitations
The study primarily focused on products purchased online, which may not represent all available oseltamivir products.
Digital Object Identifier (DOI)
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